Anomia plays off the fact that our minds are positively brimming with all sorts of random information; things to eat, pop songs, websites, etc. Sure, under normal circumstances, it's easy enough to give an example of a frozen food, or a dog breed; but you will find that your brain works a little differently under pressure!
The directions are simple. Draw a card from the center pile and flip it over. Does the symbol on your card match one on another player's card? If so, you must quickly face-off with the other player by giving an example of the person, place, or thing on their card before they can do the same for yours.